Diagnosis and treatment of myositis

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In conclusion, some indications from clinical studies suggested that paroxetine may affect brain development, but these results were inconsistent. By using a battery of assays that cover several key events of neural development in BrainSpheres we were able to detect alterations in neurite outgrowth, reduction of synaptic marker trratment and a decrease in the number of oligodendrocytes after exposure to paroxetine at relevant therapeutic concentrations.

These results identify paroxetine as a potential human developmental neurotoxicant, and suggest that the contraindication for its use should be evaluated and possibly extended far beyond the first trimester of pregnancy. In addition, we show that BrainSpheres allow to cover different aspects of brain development in one single system and constitute a novel tool to study and identify potential developmental neurotoxicants among chemicals and drugs, before their entry to the market.

The datasets generated for this study are available on request to the corresponding author. XZ: western blots, stainings, and some cultures. LS: neurite outgrowth, immunohistochemistry, and supervision XZ, VZ, and MC: diagnosis and treatment of myositis and oligodendrocytes quantification. M-GZ: oligodendrocytes quantification, writing and revision of the manuscript.

FB and PB: synapsis quantification. HH: revision of the manuscript. TH: project idea, PI funding, head of laboratory, and revision of the manuscript. DP: cultures, immunohistochemistry, neurite outgrowth analysis, statistical analysis, coordinator of the experiments, and writer of the manuscript.

Herbert Lachman (Albert Einstein College of Medicine). The study was supported by funding diagnosis and treatment of myositis the European Commission Horizon 2020 research and innovation program (grant No.

TH, HH and DP are named inventors on a patent by Johns Hopkins University on the production of mini-brains, diagnosis and treatment of myositis is licensed to AxoSim, New Orleans, LA, Diagnosis and treatment of myositis. They consult AxoSim and TH is shareholder. The remaining authors declare that the research was conducted snd the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Confocal imagines of O4 positive marker for the four different experiments used for quantification. BrainSphere myelination was quantified using a protocol adapted from Kerman et al. Myelination, is defined by the pixels overlapping between binary single-channel images of MBP staining and axons NF200 staining.

BrainSphere gene expression of SLC6A4 was quantified using qPCR. No statistically significant changes were found.

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