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If serotonin syndrome occurs, discontinue along fatty food concomitant serotonergic drug(s). Concomitant use of fatty food with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms fatty food orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction. If concomitant use is necessary, may require less frequent oliceridine dosing. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly.

If inhibitor is discontinued, consider increase oliceridine dosage until stable drug effects are achieved. Monitor fatty food signs of opioid withdrawal. Opioids may enhance the serotonergic effects of SSRIs and increase risk for fatty food quadriplegic. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered.

Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. If coadministered with strong CYP2D6 inhibitors, initiate pitolisant at 8. For patients currently taking pitolisant, reduce pitolisant dose by half upon initiating strong CYP2D6 inhibitors.

Monitor patients for signs of paroxetine fatty food. Paroxetine doses may need to be reduced. Either increases toxicity of the other by sedation. Continuously monitor vital signs during sedation and recovery period if coadministered. Fatty food may increase risk of bleeding.

Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration. Monitor patients fatty food symptoms of serotonin syndrome if SSRIs are coadministered with safinamide. Closely monitor for evidence of seizures when using bowel preps together with drugs that lower the seizure threshold.

Inhibition of CYP2D6 metabolism to tamoxifen's active metabolite, endoxifen. Assess need to reduce dose of CYP2D6-metabolized drug.

Decreased conversion fatty food tramadol to active metabolite. Consider reducing valbenazine dose based on tolerability fatty food coadministered with a strong CYP2D6 inhibitor. Either increases effects of the other by anticoagulation. Zanubrutinib-induced cytopenias increases risk of hemorrhage.

Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk. Risk of weakness, dyspnea, chest pain.

Either decreases levels of the other by unspecified interaction mechanism. Based on animal studies. Decreased conversion of oxycodone new active metabolite morphine. Monitor Closely (1)paroxetine fatty food 5-HTP both increase serotonin levels. Monitor Closely (1)abiraterone fatty food levels of paroxetine by affecting hepatic enzyme CYP2D6 metabolism.

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