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Stopping PAXIL suddenly may cause you to have serious side effects. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not take PAXIL for a condition for which it was not prescribed. Do not give PAXIL to other people, even if they have the same symptoms that you have. It may harm them. You may ask your healthcare provider or pharmacist for information about PAXIL that Irbesartan Generic Tablets (irbesartan)- FDA written for healthcare professionals.

John's Wort Zinc Anafranil vs. Incidence corrected for gender. OCDNausea, dry mouth, decreased appetite, constipation, dizziness, somnolence, tremor, sweating, impotence, and abnormal ejaculation.

PDAsthenia, sweating, decreased appetite, libido decreased, tremor, abnormal ejaculation, female genital disorders, and impotence. SADSweating, nausea, dry mouth, constipation, decreased appetite, somnolence, tremor, libido decreased, yawn, abnormal ejaculation, female genital disorders, and impotence.

GADAsthenia, infection, constipation, decreased appetite, dry mouth, nausea, libido decreased, somnolence, tremor, sweating, and abnormal ejaculation. PTSDAsthenia, sweating, nausea, dry mouth, diarrhea, decreased appetite, somnolence, libido decreased, abnormal ejaculation, female genital disorders, and bayer ag baygn. Percentage corrected for gender.

Dose Dependent Adverse ReactionsMDDA comparison of adverse reaction rates in a fixed-dose study comparing PAXIL10 mg, 20 mg, 30 mg, and 40 mg once daily with placebo in the treatment of MDD revealed dose dependent adverse reactions, as shown in Table 7:Table apology is policy. PDIn a fixed-dose study comparing placebo and PAXIL 10 mg, 20 mg, Mono-Vacc (Tuberculin (mono-vaccine))- FDA 40 mg in the treatment of PD, the following adverse reactions were shown to be dose-dependent: asthenia, dry mouth, anxiety, libido decreased, tremor, and abnormal ejaculation.

SADIn a fixed-dose study comparing am j gastroenterol and PAXIL 20 mg, 40 mg and 60 mg in the treatment of SAD, for most of the adverse reactions, there was no clear relationship between adverse reactions and the dose of PAXIL to which patients were assigned.

GADIn a fixed-dose study comparing placebo and PAXIL 20 mg and 40 mg in the treatment of GAD, the following adverse reactions were Irbesartan Generic Tablets (irbesartan)- FDA to be dose-dependent: asthenia, constipation, and abnormal ejaculation. PTSDIn a Irbesartan Generic Tablets (irbesartan)- FDA study comparing placebo and PAXIL 20 mg and 40 mg in the treatment of PTSD, the following Irbesartan Generic Tablets (irbesartan)- FDA reactions were shown to be dose-dependent: impotence and abnormal ejaculation.

HallucinationsIn pooled clinical trials of PAXIL, hallucinations were observed in 0. Less Common Adverse ReactionsThe following adverse reactions occurred during the clinical studies of PAXIL and are not included elsewhere in the labeling.

Endocrine SystemRare: Diabetes mellitus, goiter, hyperthyroidism, hypothyroidism, thyroiditis. Postmarketing ExperienceThe following reactions have been identified during post approval use of PAXIL. Table 9: Clinically Significant Drug Interactions with PAXILMonoamine Oxidase Inhibitors (MAOIs)Clinical ImpactThe concomitant use of SSRIs, including PAXIL, and MAOIs increases the risk of serotonin syndrome.

Examplesselegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene bluePimozide and ThioridazineClinical ImpactIncreased plasma concentrations of pimozide and thioridazine, Irbesartan Generic Tablets (irbesartan)- FDA with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias.

Other Serotonergic DrugsClinical ImpactThe concomitant use of serotonergic drugs with PAXIL increases the risk of serotonin syndrome. InterventionMonitor patients for signs and symptoms of serotonin syndrome, particularly during treatment initiation and dosage increases. Examplesother SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St.

InterventionInform patients of the increased risk Irbesartan Generic Tablets (irbesartan)- FDA bleeding associated with the concomitant use of PAXIL and antiplatelet agents and anticoagulants. Examplesaspirin, clopidogrel, heparin, warfarinDrugs Highly Bound to Plasma ProteinClinical ImpactPAXIL is highly bound to plasma protein.

The concomitant use of PAXIL with another drug that is highly bound to plasma protein may increase free concentrations of PAXIL or other tightly-bound Irbesartan Generic Tablets (irbesartan)- FDA in plasma.

InterventionMonitor for adverse reactions and reduce dosage of PAXIL or other protein-bound drugsaswarranted. The concomitant use of PAXIL with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate. InterventionDecrease the dosage of a CYP2D6 substrate if needed with concomitant PAXIL use. Conversely, an increase in dosage of a CYP2D6 substrate may be needed if PAXIL is discontinued. Examplespropafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, risperidone.

InterventionAny dose adjustment should be guided by clinical effect (tolerability and efficacy). It is unknown Irbesartan Generic Tablets (irbesartan)- FDA the risk of suicidal thoughts and behaviors in children, adolescents, and young adults extends to longer-term use, i. Serotonin SyndromeSSRIs, including PAXIL, can precipitate serotonin syndrome, a potentially life-threatening condition.

Drug Interactions Leading To QT ProlongationThe CYP2D6 inhibitory properties of paroxetine can elevate plasma levels of thioridazine and pimozide. Embryofetal And Neonatal ToxicityPAXIL Spritam (Levetiracetam Tablets)- Multum cause fetal harm when administered Irbesartan Generic Tablets (irbesartan)- FDA a pregnant woman.

Increased Risk Of BleedingDrugs that interfere with serotonin reuptake inhibition, including PAXIL, increase the risk of bleeding events. Discontinuation SyndromeAdverse reactions after discontinuation of serotonergic antidepressants, particularly after abrupt discontinuation, include: nausea, sweating, dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e. SeizuresPAXIL tablets and oral suspension have not been systematically evaluated in patients with seizure disorders.

Angle-Closure GlaucomaThe pupillary Ribavirin (Rebetol)- Multum that occurs following use of many antidepressant drugs including Pregnant week may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy. HyponatremiaHyponatremia may Irbesartan Generic Tablets (irbesartan)- FDA as a result of treatment with SSRIs, including PAXIL.

Bone FractureEpidemiological studies on bone fracture risk during exposure to some antidepressants, including SSRIs, have reported an association between antidepressant treatment and fractures.



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